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Effect of Gabapentin on Kidney Function Following Laparoscopic Sleeve Gastrectomy (LSG)
Sponsor: Tanta University
Summary
This study evaluated the effect of a single preoperative dose of gabapentin on renal stress and kidney function following laparoscopic sleeve gastrectomy in adults with severe obesity. Sixty participants undergoing laparoscopic sleeve gastrectomy were randomized in a 1:1 ratio to surgery without preoperative gabapentin or surgery after a single 1200-mg oral dose of gabapentin. An additional 30 non-operative participants with severe obesity served as a non-randomized external reference cohort. Renal assessment included conventional kidney function markers and biomarkers, including Dickkopf-3 (DKK3) and neutrophil gelatinase-associated lipocalin (NGAL). The prespecified primary endpoint was urinary DKK3 concentration at 24 hours postoperatively.
Official title: Clinical Study Evaluating the Effect of Gabapentin on Kidney Function Following Laparoscopic Sleeve Gastrectomy (LSG) for Morbid Obese Patients
Key Details
Gender
All
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2024-12-01
Completion Date
2025-11-30
Last Updated
2026-08-18
Healthy Volunteers
No
Conditions
Interventions
Laparoscopic Sleeve Gastrectomy
Standard laparoscopic sleeve gastrectomy performed under general anesthesia according to institutional protocol, with gastric resection over a calibration bougie.
gabapentin 1200 mg
A single oral dose of 1200 mg gabapentin administered approximately 1 hour prior to induction of anesthesia for laparoscopic sleeve gastrectomy.
Locations (2)
Mansoura University hospitals
Al Mansurah, Egypt
Tanta University hospitals
Tanta, Egypt