Clinical Research Directory

Investigating Glucose Metabolism of LEAP2 With Total-body PET/CT

Sponsor: University Hospital, Gentofte, Copenhagen

Summary

The naturally occurring hormone LEAP2 is proposed to have opposite effects to that of the 'hunger hormone' ghrelin. Other that appetite regulation, LEAP2 is involved in glucose metabolism through mechanisms yet not fully understood. With two experimental days; one recieving LEAP2 and one recieving placebo infusion in a randomized order, the study will explore the effect of LEAP2 (vs. placebo) on glucose metabolism through total-body PET/CT-scans and thereby gain a deeper understanding of the ghrelin/LEAP2 system and its interaction with glucose metabolism. Furthermore, the project will generate scanning references in individuals with obesity that are usable in forthcoming research projects.

Official title: Effects of Antagonizing the Ghrelin Receptor on Total-body Glucose Metabolism in Obesity

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