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Alcohol After Bariatric Surgery 2
Sponsor: University of Illinois at Urbana-Champaign
Summary
The goal of this observational study is to learn how the body processes ingested alcohol and how alcohol affects mood and blood sugar in both men and women after undergoing sleeve gastrectomy. The main question\[s\]it aims to answer are: * Are there differences in the way that ingested alcohol is handled in men versus women after sleeve gastrectomy? * What is the consequence of drinking alcohol on an empty stomach versus after a meal on blood sugar control after undergoing sleeve gastrectomy? Participants will participate in two types of alcohol tests (alcohol given orally or administered intravenously) after not eating anything overnight or after having a meal. Researchers will compare men and women who underwent sleeve gastrectomy with men and women who had no surgery, are of similar age and body composition, and have similar alcohol intake patterns.
Official title: Pharmacokinetics and Responses to Alcohol After Bariatric Surgery
Key Details
Gender
All
Age Range
21 Years - 64 Years
Study Type
OBSERVATIONAL
Enrollment
88
Start Date
2024-07-31
Completion Date
2028-08
Last Updated
2025-03-11
Healthy Volunteers
No
Conditions
Interventions
Alcohol (Ethanol)
Alcohol given orally (0.5 grams of alcohol per kg of fat-free mass) Alcohol given iv with a clamp ( 6% v/v alcohol prepared in 0.5% normal saline). The infusion rate will exponentially increase from the start of the infusion until the target BrAC of 0.6g/L (60mg%) is reached at 15 min, followed by an exponentially decreasing infusion rate, which will be tapered to a constant steady-state value to clamp the BrAC at the target value for a predetermined duration of 180 min.
Locations (1)
University of Illinois at Urbana Champaign
Urbana, Illinois, United States