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ACTIVE NOT RECRUITING

NCT06260722

PHASE3

Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)

Sponsor: Eli Lilly and Company

View on ClinicalTrials.gov

Summary

The purpose of this study is to investigate the efficacy and safety of retatrutide compared with semaglutide in participants with Type 2 Diabetes and inadequate glycemic control with metformin with or without sodium-glucose cotransporter-2 inhibitor (SGLT2i). The study will last about 26 months and may include up to 24 visits.

Official title: A Phase 3, Randomized, Multicenter, Open-label Study to Investigate the Efficacy and Safety of Retatrutide Once Weekly Compared With Semaglutide Once Weekly in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

1250

Start Date

2024-02-21

Completion Date

2027-01

Last Updated

2025-04-27

Healthy Volunteers

Conditions

Diabetes Mellitus, Type 2

Interventions

DRUG

Retatrutide

Administered SC.

DRUG

Semaglutide

Administered SC.

Locations (77)

University of Alabama - Department of Nutrition Sciences

Birmingham, Alabama, United States

Neighborhood Healthcare Institute of Health

Escondido, California, United States

Long Beach Research Institute

Long Beach, California, United States

Valley Clinical Trials, Inc.

Northridge, California, United States

Rancho Cucamonga Clinical Research

Rancho Cucamonga, California, United States

University of Colorado Anschutz Medical Campus

Aurora, Colorado, United States

Arrow Clinical Trials

Daytona Beach, Florida, United States

New Age Medical Research Corporation

Miami, Florida, United States

South Broward Research

Miramar, Florida, United States

Clinical Research of Central Florida

Winter Haven, Florida, United States

Herman Clinical Research

Suwanee, Georgia, United States

North Georgia Clinical Research

Woodstock, Georgia, United States

Pacific Diabetes & Endocrine Center

Honolulu, Hawaii, United States

Rocky Mountain Clinical Research

Idaho Falls, Idaho, United States

Deaconess Clinic - Gateway Health Center

Newburgh, Indiana, United States

IMA Clinical Research Monroe - Armand

Monroe, Louisiana, United States

MedStar Health Research Institute (MedStar Physician Based Research Network)

Hyattsville, Maryland, United States

Brigham and Women's Hospital Diabetes Program

Boston, Massachusetts, United States

NECCR PrimaCare Research

Fall River, Massachusetts, United States

Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

Troy, Michigan, United States

Palm Research Center Tenaya

Las Vegas, Nevada, United States

Palm Research Center Sunset

Las Vegas, Nevada, United States

NYC Research INC

Long Island City, New York, United States

Medication Management

Greensboro, North Carolina, United States

Remington Davis Clinical Research

Columbus, Ohio, United States

Alliance for Multispecialty Research, LLC

Norman, Oklahoma, United States

Central States Research

Tulsa, Oklahoma, United States

The Corvallis Clinic, P.C.

Corvallis, Oregon, United States

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, United States

Velocity Clinical Research, Dallas

Dallas, Texas, United States

Valley Institute of Research - Fort Worth

Fort Worth, Texas, United States

Juno Research

Houston, Texas, United States

Southern Endocrinology Associates

Mesquite, Texas, United States

Consano Clinical Research, LLC

Shavano Park, Texas, United States

Texas Valley Clinical Research

Weslaco, Texas, United States

Medrasa Clinical Research

Wylie, Texas, United States

Central Washington Health Services Association d/b/a Confluence Health

Wenatchee, Washington, United States

IMA Clinical Research West Virginia

Morgantown, West Virginia, United States

CARE - Centro de Alergia y Enfermedades Respiratorias

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

Stat Research S.A.