Clinical Research Directory

Inclusion Criteria: 1. Meet the DSM-5 criteria for unipolar MDD with a current major depressive episode (MDE) without psychotic features, with ≤ 2 failed treatment trials (non-treatment-resistant depression), as determined by a physician and validated by a MINI done by a trained research assistant 2. No change in the medication regimen or other forms of treatments (e.g., psychotherapy) for at least 4 weeks (28 days) prior to beginning the study, during the 20-session treatment period, and the 4-week post-treatment observation period. This will be established through self-report, in combination with the Antidepressant Treatment History Form (ATHF) form filled out by the participant. 3. Men and non-pregnant women aged \> 18 years Exclusion Criteria: * 1\. Paralysis of facial nerves 2\. Metallic implants or metal braces near the potential sites of electrical stimulation and any type of implanted electronic device 3\. Current fibromyalgia or currently receiving or have received repetitive transcranial magnetic stimulation (rTMS) within the last month (28 days) before screening 4\. Past or current symptoms of mania, hypomania, mixed episodes, psychotic disorders, active substance abuse, or dependence (excluding nicotine and caffeine) which will be confirmed on the MINI done by a trained research assistant 5\. Current suicidal intent or plan as demonstrated by a score of ≥ 2 on MADRS item 10