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Nephroureterectomy With and Without Lymph Node Dissection for Upper Tract Urothelial Cell Carcinoma
Sponsor: Case Comprehensive Cancer Center
Summary
The goal of this study is to conduct the first randomized-controlled trial to determine the oncologic efficacy of lymph node dissection in participants with upper tract urothelial cell carcinoma. The main questions it aims to answer are: * To determine oncologic outcomes, specifically 2-year recurrence-free survival * To determine other oncologic outcomes including treatment-free, cancer-specific and overall survival * To determine time to recurrence and recurrence patterns * To determine use of adjuvant therapies * To determine perioperative complications Participants will undergo nephroureterectomy with or without lymph node dissection. Researchers will compare these two groups to determine the oncologic efficacy of performing lymph node dissection.
Official title: Randomized-Controlled Trial Examining Oncologic and Perioperative Outcomes for Nephroureterectomy With and Without Lymph Node Dissection for Upper Tract Urothelial Cell Carcinoma
Key Details
Gender
All
Age Range
19 Years - Any
Study Type
INTERVENTIONAL
Enrollment
94
Start Date
2024-05-17
Completion Date
2029-01-01
Last Updated
2025-09-05
Healthy Volunteers
No
Conditions
Interventions
Nephroureterectomy
Participants will undergo standard-of-care nephroureterectomy for UTUC.
Lymph Node Dissection
Participants will receive lymph node dissection alongside nephroureterectomy for UTUC.
Locations (4)
University of Florida Health Science Center
Gainesville, Florida, United States
Southern Illinois University
Springfield, Illinois, United States
University Hospitals Cleveland Medical Center, Urology Institute, Case Comprehensive Cancer Center
Cleveland, Ohio, United States
Cleveland Clinic Glickman Urological and Kidney Institute
Cleveland, Ohio, United States