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M. Avium WGS During Mav-PD Treatment
Sponsor: University Health Network, Toronto
Summary
This is a prospective observational study using whole genome sequencing (WGS) to investigate whether new strains (other than the initially identified strain(s)) of M. avium are responsible for persistently culture positive sputum during treatment (refractory disease), or the reversion to culture positive sputum after prior conversion to negative. The study will further investigate for differences between participants living in the Toronto/York region versus participants living elsewhere. The primary goal of this prospective observational study is to understand why some patients with M. avium lung disease have persistent or recurrent M. avium in their sputum despite treatment. The aim is to understand whether it is usually due to treatment failure or new infection.
Official title: Longitudinal Assessment of Clinical Pulmonary Mycobacterium Avium Isolates in Treated Patients Using Whole Genome Sequencing
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
40
Start Date
2024-05-13
Completion Date
2026-09
Last Updated
2024-05-21
Healthy Volunteers
Not specified
Conditions
Interventions
Whole genome sequencing testing
Whole genome sequencing
Locations (1)
University Health Network
Toronto, Ontario, Canada