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A Study of Tiragolumab Plus Atezolizumab Compared With Placebo Plus Atezolizumab in Participants With Completely Resected Non-small Cell Lung Cancer Who Have Received Adjuvant Platinum-based Chemotherapy
Sponsor: Hoffmann-La Roche
Summary
The purpose of this study was to evaluate the efficacy and safety of tiragolumab plus atezolizumab compared with placebo plus atezolizumab administered to participants with non-small cell lung cancer (NSCLC) following resection and adjuvant chemotherapy.
Official title: A Phase III, Randomized, Double-blind Study of Tiragolumab Plus Atezolizumab Compared With Placebo Plus Atezolizumab in Participants With Completely Resected Stage IIB, IIIA, or Select IIIB, PD-L1 Positive, Non-small Cell Lung Cancer Who Have Received Adjuvant Platinum-based Chemotherapy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
56
Start Date
2024-03-21
Completion Date
2025-12-16
Last Updated
2026-06-10
Healthy Volunteers
No
Conditions
Interventions
Atezolizumab
Atezolizumab will be administered IV.
Tiragolumab
Tiragolumab will be administered IV.
Placebo
Placebo will be administered IV.
Locations (37)
Centro Oncologico Korben
Ciudad Autonoma Buenos Aires, Argentina
Sunshine Coast University Hospital
Birtinya, Queensland, Australia
Monash Health
Clayton, Victoria, Australia
Crio - Centro Regional Integrado de Oncologia
Fortaleza, Ceará, Brazil
Nucleo de Oncologia da Bahia - NOB
Salvador, Bahia, Estado de Bahia, Brazil
Hospital de Clínicas de Passo Fundo
Passo Fundo, Rio Grande do Sul, Brazil
Hospital Nossa Senhora da Conceicao
Porto Alegre, Rio Grande do Sul, Brazil
Hospital de Cancer de Barretos
Barretos, São Paulo, Brazil
Changzhou First People's Hospital
Changzhou, China
The First Affiliated Hospital of Sun Yat-sen University
Guangzhou, China
Shandong Cancer Hospital
Jinan, China
Yunnan Cancer Hospital
Kunming, China
Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School
Nanjing, China
Ningbo No.2 Hospital
Ningbo, China
Liaoning Provincial Cancer Hospital
Shengyang, China
Tianjin Cancer Hospital
Tianjin, China
Tongji Hospital Tongji Medical College Huazhong University of Science and Technology
Wuhan, China
Zhejiang Cancer Hospital
Zhejiang, China
Ospedale P. Pederzoli Casa di cura Privata
Peschiera Del Garda (VR), Veneto, Italy
Hiroshima University Hospital
Hiroshima, Japan
Kindai University Hospital
Osaka, Japan
Instytut Gruzlicy I Chorob Pluc
Warsaw, Poland
Pusan National University Hospital
Busan, South Korea
Kyungpook National University Chilgok Hospital
Daegu, South Korea
St. Vincent's Hospital
Gyeonggi-do, South Korea
Pusan National University Yangsan Hospital
Gyeongsangnam-do, South Korea
Seoul National University Bundang Hospital
Seongnam-si, South Korea
Seoul National University Hospital
Seoul, South Korea
Severance Hospital, Yonsei University Health System
Seoul, South Korea
Asan Medical Center
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Korea University Guro Hospital
Seoul, South Korea
E-DA Hospital
Kaohsiung City, Taiwan
Taichung Veterans General Hospital
Taichung, Taiwan
National Taiwan University Cancer Center
Zhongzheng Dist., Taiwan
Vajira Hospital
Bangkok, Thailand
Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma Hastanesi, Tibbi Onkoloji
Bakirkoy / Istanbul, Turkey (Türkiye)