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Detection of Endometrial Cancer Through Risk Modelling
Sponsor: University of British Columbia
Summary
The study goal is to investigate a non-invasive approach to predict endometrial cancer (EC) risk, better understand disease progression and identify opportunities for intervention. This two-part case-cohort prospective study will recruit patients whose abnormal uterine bleeding is being evaluated via endometrial biopsy. Participants will complete an online health questionnaire, and a subset will be invited to self-collect vaginal samples for sequencing. Selected sequenced participants will be invited for longitudinal monitoring (questionnaires, wearable fitness tracker) and an additional vaginal self-collection to identify persistent genetic mutations or microbiome alterations 6-8 months later.
Official title: Non-Invasive Strategies for Early Detection of Uterine Cancer in Patients With Abnormal Uterine Bleeding
Key Details
Gender
FEMALE
Age Range
40 Years - Any
Study Type
OBSERVATIONAL
Enrollment
1000
Start Date
2024-10-10
Completion Date
2027-01
Last Updated
2026-04-16
Healthy Volunteers
Yes
Conditions
Locations (1)
VGH Research Pavilion
Vancouver, British Columbia, Canada