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Nasal Inflammation Following Endotoxin Challenge in Patients With Asthma
Sponsor: National Jewish Health
Summary
A phase I clinical research study aimed at determining mechanisms that regulate airway mucosal inflammation in asthma endotypes using intranasal administration of endotoxin (lipopolysaccharide from E. coli) in healthy controls and subjects diagnosed with asthma.
Official title: Nasal Endotoxin Challenge to Study Mucosal Inflammation in Patients With Asthma
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2024-04
Completion Date
2028-06
Last Updated
2024-02-21
Healthy Volunteers
Yes
Conditions
Interventions
Lipopolysaccharides
LPS aka endotoxin is a component of bacterial cell walls and is ubiquitous in the environment. It is found in pet dander, house dust and environmental dusts and has been heavily studied in asthma.
Locations (1)
National Jewish Health
Denver, Colorado, United States