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Exploring the Interaction Between Metabolic Disorders and NLPR3 Inflammasome Activation in DR Inflammatory Damage
Sponsor: Zhongshan Ophthalmic Center, Sun Yat-sen University
Summary
Diabetic retinopathy (DR) is one of the most serious microvascular complications of diabetes. Early diagnosis and treatment of diabetes is the key to prevent visual impairment in DR patients. This study aims to use a non-targeted metabolomics detection technique combined with ultra-high performance liquid chromatography time-of-flight mass spectrometry to analyze the metabolomics profile in aqueous humor sample of DR patents, and further explore the mechanism of the relationship between differential metabolites and their metabolic pathways with NLRP3 activation in DR inflammatory damage. DR patients with macular edema will receive anti-vascular endothelial growth factor (anti-VEGF) treatment; these patients will be divided into two groups: responders group and non-responders group.
Official title: An Approach of Exploring the Mechanism of the Interaction Between Metabolic Disorders and NLPR3 Inflammasome Activation in DR Inflammatory Damage Based on Metabolomics Methods
Key Details
Gender
All
Age Range
40 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
240
Start Date
2024-07-03
Completion Date
2026-12-30
Last Updated
2024-07-01
Healthy Volunteers
No
Locations (1)
Zhongshan Ophthalmic Center of Sun Yat-sen University
Guangzhou, Guangdong, China