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Adding Dexmedetomidine or Tramadol to Paracetamol- An Effort to Attenuate Catheter Related Bladder Discomfort
Sponsor: Al-Azhar University
Summary
The insertion of a urinary catheter in a patient undergoing a surgical procedure, especially urinary interventions, may lead to catheter-related bladder discomfort (CRBD) with varying degrees of severity during the postoperative period. Paracetamol is a drug with proven efficacy for the management of mild and moderate postoperative pain. Tramadol is a centrally acting, synthetic opioid analgesic with weak opioid agonist properties. It inhibits the detrusor activity by inhibition of type-1 muscarinic (M1) and type-3 muscarinic (M3) receptors. Dexmedetomidine, a highly selective α2-adrenergic receptor agonist, with analgesic, sedative, anxiolysis, sympatholytic, and sedative properties, is a very useful associated agent for general anesthesia.
Official title: The Effect of Adding Dexmedetomidine or Tramadol to Paracetamol- An Effort to Attenuate Catheter Related Bladder Discomfort: A Randomized, Triple-Blind Clinical Trial
Key Details
Gender
MALE
Age Range
20 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
60
Start Date
2024-02-28
Completion Date
2026-09-30
Last Updated
2026-01-06
Healthy Volunteers
No
Conditions
Interventions
Dexmedetomidine 0.5 mic/kg
Group I (DP group) will receive dexmedetomidine 0.5 mic/kg and paracetamol 10mg/kg,
Tramadol 1mg/kg
Group II (TP group) will receive tramadol 1mg/kg and paracetamol 10mg/kg.
Paracetamol 10mg/kg
Group I (DP group) will receive dexmedetomidine 0.5 mic/kg and paracetamol 10mg/kg. Group II (TP group) will receive tramadol 1mg/kg and paracetamol 10mg/kg.
Locations (1)
Neveen Kohaf
Cairo, Cairo Governorate, Egypt