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Upfront Systematic Tumour BRCA Testing in Patients With High Grade Serous or Endometrioid Ovarian, Fallopian Tube or Primary Peritoneal Cancer (HGSEC): The t-BRCA Study
Sponsor: Cancer Trials Ireland
Summary
A pilot study to evaluate the feasibility of a NGS-based tumour BRCA1/2 mutation testing pathway initiated in the oncology clinic for patients with HGSEC, either at primary diagnosis or first relapse, whereby only patients with a positive germline BRCA1/2 mutation test will be referred to clinical genetics.
Official title: Upfront Systematic Tumour BRCA Testing in Patients With High Grade Serous or Endometrioid Ovarian, Fallopian Tube or Primary Peritoneal Cancer: The t-BRCA Study
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
200
Start Date
2019-03-22
Completion Date
2026-03-12
Last Updated
2026-04-13
Healthy Volunteers
No
Conditions
Interventions
Somatic and Germline BRCA1/2 Testing
Germline BRCA1/2 mutation testing will be undertaken by NGS using blood samples. Somatic BRCA1/2 mutation testing will be undertaken by NGS using tumour tissue.
Locations (5)
Mater Misericordiae University Hospital / Mater Private Hospital
Dublin, Leinster, Ireland
St James's Hospital
Dublin, Leinster, Ireland
Bon Secours
Cork, Munster, Ireland
Cork University Hospital
Cork, Munster, Ireland
University Hospital Limerick
Limerick, Munster, Ireland