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NCT06274541

Upfront Systematic Tumour BRCA Testing in Patients With High Grade Serous or Endometrioid Ovarian, Fallopian Tube or Primary Peritoneal Cancer (HGSEC): The t-BRCA Study

Sponsor: Cancer Trials Ireland

View on ClinicalTrials.gov

Summary

A pilot study to evaluate the feasibility of a NGS-based tumour BRCA1/2 mutation testing pathway initiated in the oncology clinic for patients with HGSEC, either at primary diagnosis or first relapse, whereby only patients with a positive germline BRCA1/2 mutation test will be referred to clinical genetics.

Official title: Upfront Systematic Tumour BRCA Testing in Patients With High Grade Serous or Endometrioid Ovarian, Fallopian Tube or Primary Peritoneal Cancer: The t-BRCA Study

Key Details

Gender

FEMALE

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

200

Start Date

2019-03-22

Completion Date

2026-03-12

Last Updated

2026-04-13

Healthy Volunteers

No

Interventions

GENETIC

Somatic and Germline BRCA1/2 Testing

Germline BRCA1/2 mutation testing will be undertaken by NGS using blood samples. Somatic BRCA1/2 mutation testing will be undertaken by NGS using tumour tissue.

Locations (5)

Mater Misericordiae University Hospital / Mater Private Hospital

Dublin, Leinster, Ireland

St James's Hospital

Dublin, Leinster, Ireland

Bon Secours

Cork, Munster, Ireland

Cork University Hospital

Cork, Munster, Ireland

University Hospital Limerick

Limerick, Munster, Ireland