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Nicotinamide Riboside (NR) to Treat Moyamoya-like Cerebrovascular Disease in Smooth Muscle Dysfunction Syndrome (SMDS)
Sponsor: The University of Texas Health Science Center, Houston
Summary
The purpose of this study is to determine whether SMDS patients treated with NR at the proposed dose exhibit decreased glucose uptake in the aorta, to determine if NR treatment results in measurable changes of blood NAD+ and NR levels, to determine if aortic measurements are stable after treatment with NR and to evaluate the safety and tolerability of NR in SMDS patients.
Key Details
Gender
All
Age Range
1 Year - Any
Study Type
INTERVENTIONAL
Enrollment
15
Start Date
2024-03-06
Completion Date
2027-07-25
Last Updated
2025-09-12
Healthy Volunteers
No
Interventions
Nicotinamide riboside (NR)
Participants will take their weight-based dose of NR once daily by mouth with food for 60 days.
Locations (1)
The University of Texas Health Science Center at Houston
Houston, Texas, United States