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Study of Brain-spinal Cord Neural Connectivity in Spasticity
Sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Summary
Little is known about the peripheral and central mechanisms of action of selective dorsal rhizotomy surgery for the treatment of spasticity. A better understanding of these mechanisms will enable us to improve the surgical procedure. This will require cortico-medullo-radiculo-muscular recordings never before performed and published in the literature, and the identification of variations in connectivity correlated with the clinic.
Key Details
Gender
All
Age Range
3 Years - 17 Years
Study Type
OBSERVATIONAL
Enrollment
50
Start Date
2024-02-26
Completion Date
2026-05
Last Updated
2025-06-11
Healthy Volunteers
No
Conditions
Interventions
intraoperative neuroelectrophysiological monitoring
The procedure involves intraoperative neuroelectrophysiological monitoring. The aim is to record the electrical activity of the central and peripheral nervous system at several levels during a neurosurgical procedure. The equipment used comes from INOMED and consists of : * a recording station (ISIS) * scalp corkscrew electrodes (2 to 4 electrodes) * a 4-pin FSR spinal cord electrode (Ad-Tech) * hook electrodes for roots/radicles (X2) * needle electrodes for muscles (X18) Electrode placement and recording take place in the operating room while the patient is under general anaesthetic (intubated and sedated).
Locations (2)
Hpu Lenval
Nice, France
HFAR
Paris, France