Clinical Research Directory

INCLUSION CRITERIA: * Adults (age ≥18 years). * Patients with IBD meeting the following criteria: * Diagnosis of IBD confirmed by clinical and histological evidence. * Disease extent (Montreal classification): 1) For Ulcerative Colitis (UC), Extensive colitis (E3): involvement proximal to the splenic flexure; or, Left-sided colitis (E2): involvement distal to the splenic flexure. 2) For Crohn's Disease (CD): Colon-only involvement (L2); or, Ileocolonic involvement (L3). * Disease duration \> 7 years. * Patients with concommitant Primary Sclerosing Cholangitis, regardless of the extent of colonic involvement and disease duration. * Written consent from the patient to undergo colonoscopy (signed informed consent). EXCLUSION CRITERIA: * Personal history of colorectal cancer (CRC). * Previous colectomy (partial or complete). * Coagulopathy preventing biopsy or polypectomy/mucosal resection. * Colonoscopy performed in the last 6 months. * Pregnant or lactating women. * Ulcerative colitis with involvement limited to the rectum or Proctitis (Montreal E1). * Inadequate colonic preparation due to uncleavable fecal residue during colonoscopy: Boston Bowel Preparation Scale (BBPS) = 0 or 1 in any colon segment. * Presence of inflammatory activity due to IBD on endoscopy:1) For UC: Endoscopic Mayo Score ≥ 2. 2) For CD: Simplified Endoscopic Activity Score (SES-CD) \> 5. * Incomplete lower digestive endoscopy (failure to reach the cecum).