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RECRUITING
NCT06282406
NA

Pupil-Indexed Noninvasive Neuromodulation

Sponsor: VA Office of Research and Development

View on ClinicalTrials.gov

Summary

Vagus nerve stimulation (VNS) is thought to activate neural pathways that release chemicals which promote plasticity and learning. Previous work has shown that the auricular branch of the vagus nerve innervates landmarks on the external ear. Work from the PI's laboratory has shown that electrical current applied to the external ear modulates physiological indexes of brain states implicated in the therapeutic effects of VNS. The broad objective of this project is to better understand physiological mechanisms modulated by auricular stimulation to support possible therapeutic effects in the form of motor learning.

Official title: Transcutaneous Auricular Vagus Nerve Stimulation: Motor Learning & Mechanisms

Key Details

Gender

All

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

110

Start Date

2024-06-03

Completion Date

2028-08-05

Last Updated

2025-06-24

Healthy Volunteers

Yes

Conditions

Interventions

OTHER

Transcutaneous Electrical Stimulation

Electrical pulse trains applied to the skin overlying putative sites of auricular vagal innervation.

OTHER

Sham

Electrodes placed on the skin overlying putative sites of auricular vagal innervation but no current administered.

Locations (1)

VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA

Pittsburgh, Pennsylvania, United States