Clinical Research Directory

Inclusion Criteria: All subjects * Sufficient command of the Dutch language * In possession of a driver's license with any driving experience throughout life * Age 18 to 65 bvYOD subjects * Probable diagnosis of young-onset dementia (before 65 years old), confirmed after interdisciplinary consensus meeting in which interviews, neuropsychological examination, neurological and psychiatric assessments, neuro-imaging, blood samples, and in some cases FDG/PIB-PETscans, CSF biomarkers or genetic counseling were discussed. * Nosological diagnosis of bvFTD or bvAD Non-bvYOD subjects * Probable diagnosis of young-onset dementia (before 65 years old), confirmed after interdisciplinary consensus meeting in which interviews, neuropsychological examination, neurological and psychiatric assessments, neuro-imaging, blood samples, and in some cases FDG/PIB-PETscans, CSF biomarkers or genetic counseling were discussed. * YOD subtypes other dan bvFTD or bvAD, such as amnestic variant AD. Frontal brain injury subjects \- Neurological patients with frontal brain injury (e.g. traumatic brain injury, stroke or brain tumor patients). Exclusion Criteria: All subjects * Suffering from severe motion sickness; motion sickness is a risk factor for simulator sickness YOD subjects: \- Presence of premorbid severe neurological or psychiatric pathology, non-related to dementia. Frontal brain injury subjects: \- Presence of serious psychiatric disorders or other neurological comorbidities. Healthy control subjects: * Presence of serious psychiatric disorders * History of neurological disorders, which may interfere with cognitive functioning (e.g. recent concussion, previous subarachnoid or intracerebral haemorrhage, intracranial tumours, epilepsy, ischemic stroke).