Clinical Research Directory

Inclusion Criteria: * Written informed consent must be obtained at screening visit, before any assessment will be performed. Subjects should be able to provide informed written consent (study participation informed consent form): Able to give written informed consent prior to participation in the study, which will include the ability to comply with the requirements and restrictions listed in the consent form. Subjects must be able to read, comprehend, and write at a level sufficient to complete study related materials. * Confirmed severe asthma diagnosis and treatment requirements according to American Thoracic Society(ATS)/European Respiratory Society (ERS) guidelines and Global Initiative for Asthma (GINA) 2023. * Blood eosinophils ≥150cells/ul at screening visit or ≥300cells/ul the last 12 months. * Patients with history ≥ 1 exacerbation the previous year under the treatment of high dose of inhaled corticosteroid(ICS)+LABA±LAMA or receiving oral/systemic corticosteroids at least 3 days. For subjects on maintenance oral corticosteroids, an exacerbation requiring oral corticosteroids was defined as the use of oral/systemic corticosteroids at least double the existing dose for at least 3 days. * Meet requirements for biologic therapy with Benralizumab. Exclusion Criteria: * Asthma exacerbation, within 6 weeks prior to screening that required hospitalization or emergency room visit. * Prior use of other biologics that has potential to interfere/ affect disease progression. * Pregnant or nursing women, or women of child-bearing potential. * History of malignancy of any organ system or any other serious co-morbidities defined by the treating physician. * Patients with a history of conditions other than asthma that could result in elevated eosinophils (e.g. hypereosinophilic syndromes, Churg-Strauss Syndrome, eosinophilic esophagitis).