Clinical Research Directory

Inclusion Criteria: * sixty-three Male and female patients aged between 40 and 65 years old were diagnosed clinically and radiologically as knee osteoarthritis grade mild and moderate chronic knee osteoarthritis. * BMI ranges between 20 and 32 kg/m2. * Knee OA grades 1 and 2 are based on Kellgren and Lawrence's grades. Narrowing of joint space, definite osteophytes. * Unilateral knee osteoarthritis. * Knee pain for most days of the prior month, in addition to at least 3 of the following: 1. Crepitus on active joint motion 2. Morning stiffness less than 30 minutes duration 3. Age older than 50 years 4. Bony enlargement of the knee on examination 5. Bony tenderness of the knee on examination 6. No palpable warmth. Exclusion Criteria: * Patients having the following conditions will be excluded from the study: * Comorbidities such as (rheumatoid arthritis, cancer, osteoporosis, and joint infection). * Previous surgery for knee OA. * BMI more than 33 kg/m2. * Suffering from polyarticular disease. * Severe mechanical deformity (diaphyseal Varus deformity of 4° and valgus of 16°). * Previous arthroscopy within the last year. * Systemic autoimmune rheumatoid disease (connective tissue disease and systemic necrotizing vasculitis).