Clinical Research Directory

Group 1: wtATTR-CM patients Inclusion Criteria: * Patients \> 18 years diagnosed with ATTRwt-CM by: * endomyocardial biopsy * DPD scintigraphy with Perugini grade 2-3 where variant amyloidosis is ruled out due to genetic testing. * Informed oral and written consent Exclusion Criteria: * AL amyloidosis (light-chain amyloidosis). * Myelomatosis * Waldenström macroglobulinemia Group 2: Control group Inclusion Criteria: * Patients \> 18 years * Informed oral and written consent Exclusion Criteria: * Known cardiovascular disease including ischemic heart disease, heart failure, atrial fibrillation, presence of a pacemaker, or malignant hypertension. Well-controlled hypertension is acceptable. * Suspicion of cardiac amyloidosis assessed through clinical history, physical examination, ECG, and echocardiography focusing on "red flags": * Echocardiography with: * Myocardial hypertrophy (septum \>11 mm) * Apical sparing in LV-GLS * Infiltrative changes in the right ventricle free wall, thickened atrioventricular valves, or thickened atrial septum * Symptoms of polyneuropathy * Low voltage on ECG or discrepancy between left ventricular thickness and ECG amplitude indicative of low voltage * Atrioventricular block (AV block) * Bilateral carpal tunnel syndrome * Surgery for spinal stenosis * Elevated troponin I or NT-pro-BNP