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ACTIVE NOT RECRUITING
NCT06293365
PHASE2

Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL PFS with1mL Pre-filled Syringe in Adult Participants With Autoimmune Disease

Sponsor: Novartis Pharmaceuticals

View on ClinicalTrials.gov

Summary

The purpose of this study is to demonstrate the comparability of ianalumab exposure following the sub-cutaneous (s.c.) administration of one injection of 300 mg/2 mL auto-injector (AI) versus two injections of 150 mg/1 mL pre-filled syringe (PFS), and to evaluate the safety and tolerability of ianalumab following the s.c. administration of both devices in participants with rheumatoid arthritis (RA), Sjögren's disease (SjD), or systemic lupus erythematosus (SLE). A second cohort will be included with the objective of demonstrating the comparability of pharmacokinetics of ianalumab between 1 x 2 mL Pre-filled Syringe (PFS) and 2 x 1 mL PFS.

Official title: A Randomized, Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL Pre-filled Syringe With 1 mL Pre-filled Syringe in Adult Participants With Autoimmune Disease

Key Details

Gender

All

Age Range

18 Years - 70 Years

Study Type

INTERVENTIONAL

Enrollment

155

Start Date

2024-07-02

Completion Date

2029-01-04

Last Updated

2025-12-04

Healthy Volunteers

No

Interventions

BIOLOGICAL

VAY736 1ml PFS

Solution for injection.

BIOLOGICAL

VAY736 2 ml PFS

Solution for injection

BIOLOGICAL

VAY736 2ml AI

Solution for injection.

Locations (37)

Pinnacle Research Group Llc

Anniston, Alabama, United States

Providence Medical Foundation

Fullerton, California, United States

Advanced Medical Research

La Palma, California, United States

Conquest Research

Winter Park, Florida, United States

Parris and Associates Rheumatology

Lawrenceville, Georgia, United States

Indiana Univ School of Dentistry

Indianapolis, Indiana, United States

Ochsner Health System

Baton Rouge, Louisiana, United States

Ahmed Arif Medical Research Center

Grand Blanc, Michigan, United States

Paramount Med Rsrch and Consult LLC

Middleburg Heights, Ohio, United States

RAO Research LLC

Oklahoma City, Oklahoma, United States

Altoona Center for Clin Res

Duncansville, Pennsylvania, United States

West Tennessee Research Institute

Jackson, Tennessee, United States

Shelby Research LLC

Memphis, Tennessee, United States

Novel Research LLC

Bellaire, Texas, United States

Southwest Rheum Rsrch LLC

Mesquite, Texas, United States

Uni of Texas Health Science Center

San Antonio, Texas, United States

Advanced Rheumatology of Houston

Spring, Texas, United States

Novartis Investigative Site

Quilmes, Buenos Aires, Argentina

Novartis Investigative Site

San Miguel de Tucumán, Tucumán Province, Argentina

Novartis Investigative Site

Buenos Aires, Argentina

Novartis Investigative Site

Buenos Aires, Argentina

Novartis Investigative Site

Hamilton, Ontario, Canada

Novartis Investigative Site

Toronto, Ontario, Canada

Novartis Investigative Site

Rimouski, Quebec, Canada

Novartis Investigative Site

Trois-Rivières, Quebec, Canada

Novartis Investigative Site

Brno, Czechia

Novartis Investigative Site

Prague, Czechia

Novartis Investigative Site

Uherské Hradiště, Czechia

Novartis Investigative Site

Debrecen, Hajdu Bihar Megye, Hungary

Novartis Investigative Site

Budapest, Hungary

Novartis Investigative Site

Budapest, Hungary

Novartis Investigative Site

Salerno, SA, Italy

Novartis Investigative Site

Krakow, Poland

Novartis Investigative Site

Lublin, Poland

Novartis Investigative Site

Santiago Compostela, A Coruna, Spain

Novartis Investigative Site

A Coruña, Spain

Novartis Investigative Site

Madrid, Spain