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Klinefelter Syndrome and Testosterone Treatment in Puberty
Sponsor: Lise Aksglæde
Summary
The goal of this randomized clinical trial is to study the effect of testosterone replacement therapy during puberty in boys with Klinefelter syndrome (KS, 47,XXY). The main questions to answer are how treatment with testosterone will affect body fat mass, lipid and glucose metabolism, growth and body proportions, bone mineralization as well as effects on neurocognitive development and emotional and social difficulties. Participants will be randomized to two years treatment with testosterone or placebo.
Official title: Klinefelter Syndrome - the Effect of Testosterone Treatment in Puberty. a Randomized, Double-blind Placebo-controlled Intervention Study: 'The TiPY Study'
Key Details
Gender
MALE
Age Range
10 Years - 14 Years
Study Type
INTERVENTIONAL
Enrollment
32
Start Date
2024-08-15
Completion Date
2029-12-31
Last Updated
2025-02-19
Healthy Volunteers
No
Conditions
Interventions
Testosterone gel
Two years treatment with testosterone
Placebo
Two years treatment with placebo
Locations (1)
Copenhagen University Hospital, Rigshospitalet
Copenhagen, Denmark