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Pharmacological Treatment Targeting Endotypic Traits of Obstructive Sleep Apnea
Sponsor: China Medical University Hospital
Summary
This study will conduct 3 intervention trials with 44 different participants in each trial, with 22 participants will undergo in-laboratory overnight polysomnograms (PSGs) at one night of medication intervention, and the other 22 at taking placebo (contained starch) 1 h before sleep. Three medication regimens will be tested: (1) atomoxetine 80mg combined with oxybutynin 5mg; (2) venlafaxine 37.5mg; and (3) oxybutynin 5mg combined with trazodone 100mg. Endotypic traits will be estimated using the Phenotyping Using Polysomnography method. The primary outcome is the change in apnea-hypopnea index, and secondary outcomes include endotypic traits and sleep parameters.
Key Details
Gender
All
Age Range
20 Years - Any
Study Type
INTERVENTIONAL
Enrollment
45
Start Date
2024-11-05
Completion Date
2025-10-22
Last Updated
2026-04-23
Healthy Volunteers
No
Conditions
Interventions
Atomoxetine 80mg combined with oxybutynin 5mg
Atomoxetine 80mg combined with oxybutynin 5mg
Venlafaxine 37.5mg
Venlafaxine 37.5mg
oxybutynin 5mg combined with trazodone 100mg
oxybutynin 5mg combined with trazodone 100mg
Placebo
Placebo tablet
Locations (1)
China Medical University Hospital
Taichung, Taiwan