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The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain
Sponsor: Cairo University
Summary
Pain is a very important factor in Endodontic treatment, Both intra- and Post-operatively. In case of symptomatic Irreversible pulpitis, a build up of inflammatory mediators makes it very difficult for the operator to reach the desired level of anesthesia in order to deliver a pain free treatment as well as to eliminate or at least reduce post-operative pain incidence and severity. therefore, a number of pre- medications was suggested with variable success rates. Therefore this trial aims at the use of a new category of anti-inflammatory medications which would be less harmful than the standard NSAIDs or steroids.
Official title: The Effect of Premedication With Trypsin, Bromelain and Rutoside Combination on the Success of IAN Block and Post Endodontic Pain in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
120
Start Date
2025-06-15
Completion Date
2026-01-15
Last Updated
2025-11-19
Healthy Volunteers
Yes
Conditions
Interventions
Trypsin, Bromelain and Rutoside
Flamogen is a combination of trypsin 48 mgs, bromelain 90mg and rutoside 100 mg in one tablet that provides an anti inflammatory, anti edematous activity. each patient will receive a single dose of 2 tablets one hour before treatment.
Diclofenac Potassium
Non-steroidal anti inflammatory drug. cataflam is known for its potent anti inflammatory and analgesic properties. each patient will receive one tablet of cataflam 50 mg 1 hour before treatment.
Prednisolone Oral Tablet
Steroids are potent anti inflammatory drugs, patients are going to receive one tablet of 30 mg solupred one hour before treatment
Placebo
A tablet of Compacted powdered milk
Locations (2)
Faculty of Oral and Dental Medicine, Egyptian Russian University
Cairo, Cairo Governorate, Egypt
Faculty of Dentistry, Cairo University
Cairo, Egypt