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The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain
Sponsor: Cairo University
Summary
Pain is a very important factor in Endodontic treatment, Both intra- and Post-operatively. In case of symptomatic Irreversible pulpitis, a build up of inflammatory mediators makes it very difficult for the operator to reach the desired level of anesthesia in order to deliver a pain free treatment as well as to eliminate or at least reduce post-operative pain incidence and severity. therefore, a number of pre- medications was suggested with variable success rates. Therefore this trial aims at the use of a new category of anti-inflammatory medications which would be less harmful than the standard NSAIDs or steroids.
Official title: The Effect of Premedication With Trypsin, Bromelain and Rutoside Combination on the Success of IAN Block and Post Endodontic Pain in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
124
Start Date
2025-06-15
Completion Date
2026-03-15
Last Updated
2026-05-20
Healthy Volunteers
Yes
Conditions
Interventions
Trypsin, Bromelain and Rutoside
Flamogen is a combination of trypsin 48 mgs, bromelain 90mg and rutoside 100 mg in one tablet that provides an anti inflammatory, anti edematous activity. each patient will receive a single dose of 2 tablets one hour before treatment.
Diclofenac Potassium 50mg Tab
Non-steroidal anti inflammatory drug. Cataflam is known for its potent anti inflammatory and analgesic properties. each patient will receive one tablet of Cataflam 50 mg 1 hour before treatment.
Prednisolone Oral Tablet
Steroids are potent anti inflammatory drugs, patients are going to receive one tablet of 20 mg solupred one hour before treatment
Placebo
An opaque white capsule filled with starch
Locations (2)
Faculty of Oral and Dental Medicine, Egyptian Russian University
Cairo, Cairo Governorate, Egypt
Faculty of Dentistry, Cairo University
Cairo, Egypt