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Hemodynamic Assessment of underLying myocyTe Function in Right Heart Failure
Sponsor: Johns Hopkins University
Summary
Right ventricular (RV) failure is recognized to worsen patient outcomes in the setting of heart failure with reduced ejection fraction (HFrEF)-related pulmonary hypertension (PH), yet the investigators fall short in trying to identify and treat it. The current proposal will (1) determine the best clinical indicators of intrinsic RV myocyte contractile failure in humans with HFrEF-PH, (2) clarify underlying mechanisms, and (3) test novel treatments on RV myocytes. The long-term goal of this proposal will be to better identify and treat RV failure in humans suffering from HFrEF-PH.
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
50
Start Date
2024-12-10
Completion Date
2029-03-31
Last Updated
2026-01-12
Healthy Volunteers
No
Conditions
Locations (1)
Johns Hopkins Hospital
Baltimore, Maryland, United States