Clinical Research Directory

Inclusion Criteria: Both males and females. * Diabetic and non-diabetic patients. * Age \>18 years old. * Overweight and obese patient: Body mass index (BMI) ≥ 25 kg/ m2 but \<40 kg/ m2. * Patients with heartburn, peptic ulcer, gastrointestinal reflux disease, erosive esophagitis, Zollinger-Ellison syndrome and helicobacter pylori infection. * Patients with established diagnosis of NASH based on liver ultrasonography, mild to moderate elevation in aminotransferase activities (\>2 but \<5 times upper limit of normal), hepatic steatosis index (HIS) \>36, HAIR score of 2 or 3. Exclusion Criteria: * Patients with a history of hypersensitivity to esomeprazole. * Patients with BMI ≥ 40 kg/ m2. * Patients taking warfarin, clopidogrel, digoxin, diazepam and phenytoin to avoid drug-drug interactions as these drugs are CYP2C19 substrates. * Patients infected with human immune deficiency virus taking antiretroviral medicines or dosage forms containing rilpivirine. * Patients with a history of viral hepatitis, autoimmune hepatitis, sclerosing cholangitis, biliary obstruction, primary biliary cirrhosis, hemochromatosis, Wilson's disease and alpha-1 antitrypsin deficiency. * Patients on medications associated with steatosis such as NSAIDs, amiodarone, tamoxifen, estrogen, sodium valproate, corticosteroids, and methotrexate. * Patients with cancer or with a history of cancer. * Patients with cardiovascular diseases. * Pregnant and lactating females