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Profiling Microbiome Associated Metabolic Pathways in Oesophageal Cancer Survivors
Sponsor: Imperial College London
Summary
The goal of this observational study is to learn about long term symptoms in oesophageal cancer survivors. The main question it aims to answer is are: * Study the changes in gut bacteria by examining saliva, stool and blood. * Investigate the products of bacteria in breath to develop a non-invasive breath test to detect the changes in gut bacteria. * Develop new strategies to treat this change and trial new treatments to improve quality- of-life in oesophageal cancer survivors. Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of breath, saliva, blood, urine, stool and complete validated healthy-related quality-of-life questionnaires. Researchers will compare symptomatic and asymptomatic participants to detect the changes stated above.
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2022-03-09
Completion Date
2025-12-01
Last Updated
2025-01-27
Healthy Volunteers
No
Interventions
Breath test
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of breath.
Saliva sample
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of saliva.
Blood sample
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of blood.
Urine sample
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of urine.
Stool sample
Participants will attend an outpatient clinic, fasted for at least 4 hours for collection of stool.
Health-related Quality of life questionnaires
Participants will attend an outpatient clinic and complete validated healthy-related quality-of-life questionnaires.
Locations (3)
Barking, Havering and Redbridge University Hospitals NHS Trust
London, United Kingdom
Imperial College Healthcare NHS Trust
London, United Kingdom
West Hertfordshire NHS Teaching Hospitals
London, United Kingdom