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RECRUITING
NCT06306625
NA

REmote COnditioning in Out-of-Hospital Cardiac Arrest

Sponsor: Hospices Civils de Lyon

View on ClinicalTrials.gov

Summary

Out-of-Hospital Cardiac Arrest remains a major public health problem, resulting in high mortality largely related to multiple organ failure and poor neurological outcomes due to brain anoxia. The pathophysiology of organ dysfunction after resuscitated out-of-hospital cardiac arrest involves ischemia-reperfusion processes. Remote ischemic conditioning is a therapeutic strategy used to protect organs against the detrimental effects of ischemia-reperfusion injury. The objective of the present trial is to determine whether remote ischemic conditioning performed early after out-of-hospital cardiac arrest can decrease mortality, or multiple organ failure and/or severe neurological failure.

Official title: REmote Ischemic COnditioning in Out-of-Hospital Cardiac Arrest: The RECO-OHCA Study

Key Details

Gender

All

Age Range

18 Years - 80 Years

Study Type

INTERVENTIONAL

Enrollment

220

Start Date

2024-06-21

Completion Date

2026-10-05

Last Updated

2025-02-12

Healthy Volunteers

No

Interventions

DEVICE

Remote ischemic conditioning

A brachial cuff is positioned around one arm of the patient. Remote ischemic conditioning consists of four cycles of a 5-min brachial cuff inflation at 200 mmHg followed by a 5-min of cuff deflation, and is started as soon as possible after randomization. The intervention is repeated 12 and 24 hours after inclusion.

DEVICE

No remote ischemic conditioning

A brachial cuff is positioned around the arm of the patient and no inflation or deflation is performed.

Locations (14)

Hôpital Louis Pradel

Bron, France

Hôpital Gabriel Montpied, CHU de Clermont Ferrand

Clermont-Ferrand, France

Centre Jean Perrin, Clermont-Ferrand

Clermont-Ferrand, France

Hôpital F Mitterrand, CHU de Dijon

Dijon, France

Hôpital Albert Michallon, CHU de Grenoble

La Tronche, France

Hôpital Edouard Herriot

Lyon, France

Hôpital Saint-Joseph Saint-Luc

Lyon, France

Hôpital de la Timone, CHU de Marseille

Marseille, France

Hôpital lapeyronie, CHU de Montpellier

Montpellier, France

Hôpital Universitaire Carémeau

Nîmes, France

Hôpital Lariboisière, APHP, Réanimation Médicale et Toxicologique

Paris, France

Hôpital Lyon-Sud

Pierre-Bénite, France

Hôpital Nord, CHU de St Etienne

Saint-Priest-en-Jarez, France

Hôpital Nord-Ouest

Villefranche-sur-Saône, France