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REmote COnditioning in Out-of-Hospital Cardiac Arrest
Sponsor: Hospices Civils de Lyon
Summary
Out-of-Hospital Cardiac Arrest remains a major public health problem, resulting in high mortality largely related to multiple organ failure and poor neurological outcomes due to brain anoxia. The pathophysiology of organ dysfunction after resuscitated out-of-hospital cardiac arrest involves ischemia-reperfusion processes. Remote ischemic conditioning is a therapeutic strategy used to protect organs against the detrimental effects of ischemia-reperfusion injury. The objective of the present trial is to determine whether remote ischemic conditioning performed early after out-of-hospital cardiac arrest can decrease mortality, or multiple organ failure and/or severe neurological failure.
Official title: REmote Ischemic COnditioning in Out-of-Hospital Cardiac Arrest: The RECO-OHCA Study
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
220
Start Date
2024-06-21
Completion Date
2026-10-05
Last Updated
2025-02-12
Healthy Volunteers
No
Conditions
Interventions
Remote ischemic conditioning
A brachial cuff is positioned around one arm of the patient. Remote ischemic conditioning consists of four cycles of a 5-min brachial cuff inflation at 200 mmHg followed by a 5-min of cuff deflation, and is started as soon as possible after randomization. The intervention is repeated 12 and 24 hours after inclusion.
No remote ischemic conditioning
A brachial cuff is positioned around the arm of the patient and no inflation or deflation is performed.
Locations (14)
Hôpital Louis Pradel
Bron, France
Hôpital Gabriel Montpied, CHU de Clermont Ferrand
Clermont-Ferrand, France
Centre Jean Perrin, Clermont-Ferrand
Clermont-Ferrand, France
Hôpital F Mitterrand, CHU de Dijon
Dijon, France
Hôpital Albert Michallon, CHU de Grenoble
La Tronche, France
Hôpital Edouard Herriot
Lyon, France
Hôpital Saint-Joseph Saint-Luc
Lyon, France
Hôpital de la Timone, CHU de Marseille
Marseille, France
Hôpital lapeyronie, CHU de Montpellier
Montpellier, France
Hôpital Universitaire Carémeau
Nîmes, France
Hôpital Lariboisière, APHP, Réanimation Médicale et Toxicologique
Paris, France
Hôpital Lyon-Sud
Pierre-Bénite, France
Hôpital Nord, CHU de St Etienne
Saint-Priest-en-Jarez, France
Hôpital Nord-Ouest
Villefranche-sur-Saône, France