Clinical Research Directory

Inclusion Criteria: * Contraindication to duraplasty and shunting treatment due to history or high risk of severe adverse effects, * non-effective response to duraplasty and shunting treatment in 12 months prior to study entry. * Estimated life expectancy must be greater than 12 months. * Ability to understand and willingness to sign a written informed consent document, or constant caregivers who well understand and willingness to sign a written informed consent document. * Must be able to swallow tablets Exclusion Criteria: * Participants have a cardiometabolic disease for which they take prescribed medications * Evidence of tumor metastasis, recurrence, or invasion; * History of psychiatric diseases ; * History of seizures; * History of arteriosclerotic cardiovascular diseases (ASCVD), e.g. stroke, myocardial infaction, unstable angina, within 6 months; * New York Heart Association Grade II or greater congestive heart failure; * Serious and inadequately controlled cardiac arrhythmia; * Significant vascular disease, e.g. moderate or severe carotid stenosis, aortic aneurysm, -history of aortic dissection; * Severe infection; * History of allergy to relevant drugs; * Pregnancy, lactation, or fertility program in the following 12 months; * History or current diagnosis of peripheral nerve disease; * Abnormal in liver and renal function; * Active tuberculosis; * Transplanted organs; * Human immunodeficiency virus; * Participation in other experimental studies.