Clinical Research Directory

Inclusion Criteria: * Children aged 12 to 17 at time of inclusion. * Patients with colonoscopy for diagnosis or follow-up of FAP. * ≥ 5 polyps (\> 2 mm) at initial colonoscopy (V1). * Free and informed consent, signed by both holders of parental authority/legal representative, with the accord of the minor patient. * Affiliated with a social security scheme. * Patients of childbearing potential must agree to the use of a method of contraception during the study. Exclusion Criteria: * Inability to understand the nature and goals of the study and/or communication difficulties observed by the investigator. * Contraindication to performing a colonoscopy. * \< 5 polyps (\>2 mm) registered during initial colonoscopy (V1). * Advanced disease with high-grade dysplasia adenoma or even adenocarcinoma in situ that should required colectomy * Signs of primary tuberculosis infection or respiratory infection * Any other medical or psychological condition deemed incompatible with the proper conduct of the study according to the investigator. * Contraindications to rapamycin use * Participation in other biomedical research * Deprivation of liberty of the legal guardians by judicial or administrative decision. * Pregnancy, breastfeeding