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Microbiota Directed Food for Children With Severe Acute Malnutrition
Sponsor: International Centre for Diarrhoeal Disease Research, Bangladesh
Summary
Severe acute malnutrition (SAM) refers to a condition characterized by a significant deficit in weight-for-length measurements in children aged 6 to 59 months. It is a crucial public health concern with detrimental effects on child growth, development, and overall well-being. Addressing SAM is crucial to prevent its progression to other childhood morbidity and mortality and to ensure healthy child development. To meet the nutritional requirement of SAM children, icddr,b have come up with a novel intervention named microbiota-directed food (MDF), a ready-to-use therapeutic food. The investigators propose this proof-of-concept trial to establish evidence on the effect of this novel intervention on ponderal growth, microbial and proteomic recovery among the children with SAM in comparison to the standard RUTF.
Official title: Proof-of-Concept Study for a Microbiota-Directed Food in Children With Uncomplicated Severe Acute Malnutrition in Rural Bangladesh
Key Details
Gender
All
Age Range
6 Months - 24 Months
Study Type
INTERVENTIONAL
Enrollment
256
Start Date
2024-04-15
Completion Date
2026-12-31
Last Updated
2024-03-13
Healthy Volunteers
No
Conditions
Interventions
Microbiota-Directed Food
MDF is a microbiota directed food for malnourished children aged 6 months and above. It is in sachet form. The sachet contains 92 gm of supplements and provides approximately 506 kcal.
Ready-to-Use Therapeutic Food
RUTF is standard ready-to-use therapeutic food for SAM children aged 6 months and above.
Locations (1)
Kurigram Study site
Kurigrām, Bangladesh