Clinical Research Directory

Inclusion Criteria: 1. Age ≥18 years old, male or female; 2. Outpatients diagnosed with primary hypertension who have not received treatment or are receiving antihypertensive medication; 3. Mild to moderate hypertensive patients with substandard blood pressure: home blood pressure \>140/90 mmHg at least once in the last month or more, and the average sitting blood pressure in the clinic on the day of enrollment is \>140/90 mmHg; 4. Expected survival \> 12 months; 5. Voluntary participation in the trial and signing the informed consent form. Exclusion Criteria: 1. Severe hypertension (mean SBP ≥180mmHg, or mean DBP ≥110mmHg), hypertensive emergency or hypertensive sub-emergency (systolic blood pressure \>180 mmHg or diastolic blood pressure \>120 mmHg); 2. Have a history or diagnosis of secondary hypertension, including but not limited to the following: renal hypertension, renal vascular hypertension, aortic stenosis, pheochromocytoma, Cushing's syndrome, cystic nephropathy, etc., but drug-induced hypertension is not an exclusion criterion; 3. Patients in the acute stage of the disease requiring emergency medical consultation; 4. patients with mental disorder, hearing impairment, intellectual disability, aphasia, etc., resulting in the inability to communicate or to comply with the study agreement 5. Patients with tumors; 6. Any other reasons that the investigator considers unsuitable for participation in the clinical trial that may affect the efficacy and safety evaluation of the study (including, but not limited to, the investigator's judgment that the subject lives far away and cannot be followed up as scheduled).