Clinical Research Directory
Browse clinical research sites, groups, and studies.
Exercise to Boost Immunity in Advanced Cancer
Sponsor: Sheffield Teaching Hospitals NHS Foundation Trust
Summary
The trial is a prospective feasibility trial conducted in Sheffield. Recruitment will include twenty patients receiving first line palliative immunotherapy for advanced, unresectable or metastatic mesothelioma and patients receiving first line systemic anti-cancer treatment for pancreatic cancer. Patients will attend the AWRC for a supervised exercise session once a week to include aerobic exercise along with an unsupervised weekly exercise session for 3 months. Blood samples will be collected at baseline and then monthly for 3 months, pre and post the supervised exercise session. Cytokine, myokine and immune cell concentration will be analysed using cytokine bead-based multiplex immune assays and RNA-seq to full profile changes in gene and protein expression
Official title: Exercise to Boost Immunity in Advanced Cancer: Feasibility of Combined Aerobic Exercise and Resistance Training for Patients with Advanced Mesothelioma and Pancreatic Cancer
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2025-09-01
Completion Date
2027-03-01
Last Updated
2024-12-03
Healthy Volunteers
No
Conditions
Interventions
Exercise
Exercise programme is the intervention for this study
Locations (2)
Cancer Research Centre at Weston Park Hospital
Sheffield, England, United Kingdom
Sheffield Hallam University
Sheffield, South Yorkshire, United Kingdom