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Understanding Ozanimod's MOA Via Mass Cytometry in Ulcerative Colitis
Sponsor: University of California, San Diego
Summary
The goal of this observational study is to learn about the mechanism of action of ozanimod in patients with ulcerative colitis (UC). The main questions it aims to answer are: 1. Prospectively assess the effects of ozanimod on the cellular composition of intestinal lamina propria and blood by deep immunophenotyping (CyTOF) of immune cell subsets prior and after the drug's administration. 2. Determine whether changes in cell subsets observed via mass cytometry correlate with with clinical or histologic parameters of disease activity. Colonic biopsies and peripheral blood samples will be collected from patients with UC before and after the onset of ozanimod. Researchers will compare intestinal and peripheral leukocytes before and after the drug's administration.
Official title: High Dimensional Mass Cytometry as a Tool to Understand Ozanimod's Mechanism of Action (MOA)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
10
Start Date
2023-10-06
Completion Date
2026-09-30
Last Updated
2024-03-15
Healthy Volunteers
No
Locations (1)
University of California San Diego
San Diego, California, United States