Clinical Research Directory

Inclusion Criteria: * ECOG functional status score was 0-1. * Histologically confirmed stage IV primary NSCLC; * Genetic testing showed that the common driver genes including EGFR, ALK and ROS-1 were negative; * Patients with brain metastases were eligible if they were neurologically asymptomatic and had stable disease without receiving systemic glucocorticoids; * According to the investigator's judgment, the patient does not need to receive palliative radiotherapy for any site at present; * Male/female of childbearing age agreed to use contraception (surgical ligation or oral contraceptive/intrauterine device plus condom) during the trial; * Life expectancy ≥3 months; * One week before enrollment, the organ function level met the following criteria: ① Bone marrow function: hemoglobin ≥80g/L, white blood cell count ≥4.0\*10\^9/L or neutrophil count ≥1.5\*10\^9/L, platelet count ≥100\*10\^9/L; ② Liver: serum total bilirubin level ≤1.5 times upper limit of normal, direct bilirubin level must be ≤1.5 times upper limit of normal, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤2.5 times upper limit of normal; ③ Kidney: serum creatinine \< 1.5 times upper limit of normal or creatinine clearance ≥50ml/min, urea nitrogen ≤200mg/L; Serum albumin ≥30g/L; * Patients must be able to understand and voluntarily sign the informed consent form. Exclusion Criteria: * The patient had severe autoimmune diseases: active inflammatory bowel disease (including Crohn's disease, ulcerative colitis), rheumatoid arthritis, scleroderma, systemic lupus erythematosus, autoimmune vasculitis (such as Wegener's granulomatosis), etc. * Symptomatic interstitial lung disease or active infectious/non-infectious pneumonia; * Patients with risk factors for intestinal perforation: active diverticulitis, intra-abdominal abscess, gastrointestinal (GI) obstruction, abdominal cancer, or other known risk factors for intestinal perforation; * History of other malignant tumors; * Patients with active infection, heart failure, myocardial infarction, unstable angina or unstable arrhythmia within the past 6 months; * Medical examination or clinical findings, or other uncontrollable conditions that the investigator considers may interfere with the results or increase the patient's risk of treatment complications; * Patients who were considered by the investigator to have lesions requiring palliative and subtractive radiotherapy; * Mixed with small cell lung cancer components; * Lactating or pregnant women; * Congenital or acquired immunodeficiency diseases including human immunodeficiency virus (HIV), organ transplantation or allogeneic stem cell transplantation; * Known HBV, HCV, active pulmonary tuberculosis infection; * Patients had received a cancer vaccine or received another vaccine within 4 weeks before starting treatment (note: injectable seasonal influenza vaccine is usually inactivated, so vaccination is allowed, while intranasal vaccine is usually live attenuated, so it is not allowed); * Patients with concurrent use of other immune agents, chemotherapy drugs, drugs in other clinical studies, and long-term use of cortisol were excluded. * Patients with mental disorders, substance abuse, or social problems that affect adherence were excluded from the study after physician review; * Patients who are allergic to or contraindicated to PD-1 monoclonal antibody or chemotherapy drugs.