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Sparking Gut Bacteria Production of Bioactive Xenolipids in Situ
Sponsor: University of California, Davis
Summary
Long-chain cyclopropane fatty acids (CpFAs) are microbially-derived lipids (fats), some of which can be found in select foods and appear to be produced naturally in the gut from dietary fatty acid precursors. Some of these lipids appear to have signaling properties in the body's tissues, i.e., to help regulate cardiometabolic health. Thus, increasing the bioavailability of CpFAs in humans may have utility to improve management of blood sugar and blood lipids, or to mitigate or prevent non-alcoholic fatty liver disease (NAFLD). This study is a proof-of-principle experiment in 10 subjects, to feed dietary fats thought to enhance upper gut CpFA production. The latter will be monitored through post-meal blood and urine CpFA concentration measurements, as well as concentration in the stool.
Key Details
Gender
All
Age Range
18 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2024-04-01
Completion Date
2025-05-31
Last Updated
2024-12-06
Healthy Volunteers
Yes
Conditions
Interventions
Dietary fat positive control
Dietary fat-containing meal plan with a specific supplement that may modify fat metabolism
Dietary fat negative control
Dietary fat-containing meal plan with a specific supplement that should not modify fat metabolism
Locations (1)
University of California, Davis School of Medicine
Sacramento, California, United States