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ACTIVE NOT RECRUITING
NCT06315426
PHASE2

A Study of IL4Rα Monoclonal Antibody in Patients With Seasonal Allergic Rhinitis(SAR).

Sponsor: Genrix (Shanghai) Biopharmaceutical Co., Ltd.

View on ClinicalTrials.gov

Summary

Allergic rhinitis (AR) is a non-infectious chronic inflammatory disease of the nasal mucosa mainly mediated by immunoglobulin E after exposure to allergens in atopic individuals. The typical symptoms of AR are paroxysmal sneezing, watery rhinorrhea, itching, and nasal congestion, which may be accompanied by ocular symptoms, including eye itching, tearing, redness, and burning sensation, which are more common in patients with hay fever allergies. Bronchial asthma is associated with bronchial asthma in 40% of patients with AR, suggesting a comorbid feature of allergic disease.

Official title: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase II Clinical Trial to Evaluate the Efficacy and Safety of GR1802 Injection in Combination With Background Therapy in Patients With SAR.

Key Details

Gender

All

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

240

Start Date

2024-03-24

Completion Date

2025-10

Last Updated

2025-04-25

Healthy Volunteers

No

Interventions

BIOLOGICAL

GR1802 injection

Recombinant fully human anti-IL4Rα monoclonal antibody drug.

BIOLOGICAL

Placebo

Placebo

Locations (15)

Hebei Petro China Central Hospital

Langfang, Hebei, China

Central Hospital of Qinghe County

Xingtai, Hebei, China

Zhengzhou Central Hospital

Zhengzhou, Henan, China

Jingzhou Central Hospital

Jingzhou, Hubei, China

The Central Hospital of Wuhan

Wuhan, Hubei, China

Wuhan Union Hospital of China

Wuhan, Hubei, China

Qilu Hospital of Shandong University

Jinan, Shandong, China

Shandong Second Provincial General Hospital

Jinan, Shandong, China

Liaocheng People's Hospital

Liaocheng, Shandong, China

Heping Hospital Affiliated to Changzhi Medical College

Changzhi, Shanxi, China

First Hospital of Shanxi Medical University

Taiyuan, Shanxi, China

Shanxi Bethune Hospital

Taiyuan, Shanxi, China

Xi'an Daxing Hospital

Xi’an, Shanxi, China

Yuncheng Central Hospital

Yuncheng, Shanxi, China

Chengdu Second People's Hospital

Chengdu, Sichuan, China