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Hemodynamic Effects of Apnoeic Oxygenation With High-flow Nasal Oxygen in Adults Undergoing Laryngeal Surgery
Sponsor: Region Stockholm
Summary
During apnoeic oxygenation there is a continuous raise in carbon dioxide with subsequent respiratory acidosis. The hypercapnia and respiratory acidosis have several dose-related effects on both the systemic and the pulmonary circulation and the heart that ultimately, if unrecognised, can result in cardiovascular collapse and fatal arrhythmias. In our knowledge, no studies have investigated the haemodynamic effects of apnoeic oxygenation with HFNO. The general purpose of this project is to investigate haemodynamic alternations during apnoeic oxygenation with HFNO compared to mechanical ventilation in relatively healthy patients under general anaesthesia during laryngeal surgery.
Official title: Hemodynamic Effects of Apnoeic Oxygenation With High-flow Nasal Oxygen in Adults Undergoing Laryngeal Surgery - a Randomised Study
Key Details
Gender
All
Age Range
18 Years - 110 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2024-03-25
Completion Date
2025-01-31
Last Updated
2026-05-15
Healthy Volunteers
No
Conditions
Interventions
Apnoeic oxygenation with high-flow nasal oxygen
The subjects in the intervention group will be oxygenated with HFNO during the surgical procedure.
Mechanical ventilation
Study subjects in the comparator group will be tracheally intubated and mechanically ventilated
Locations (1)
Karolinska Universitetssjukhuset Huddinge
Stockholm, Sweden