Clinical Research Directory

Inclusion Criteria: 1. Voluntarily participate and sign an informed consent form in writing; 2. Age 18 and above, regardless of gender; 3. Diagnosed as primary lung cancer through imaging/pathology, meeting the indications for SBRT and surgical treatment; 4. The clinical staging is cIB-IIIB stage (cT2-3N0M0), regardless of whether the staging is overestimated or underestimated as confirmed by pathology; 5. Imaging diagnosis of NSCLC patients with tumor invasion of interlobular pleura; 6. No serious abnormalities in the blood system, heart, lungs, liver, kidney function, or immune deficiency; 7. There are no restrictions on surgical methods, and both VATS and open chest surgery are acceptable; 8. Physical condition score ECOG level 0-2; 9. Expected survival time\>3 months. Exclusion Criteria: 1. Pathological confirmation of small cell lung cancer; 2. Non solitary lung cancer, non primary lung cancer, with distant metastasis; 3. Individuals with a history of severe lung or heart disease; 4. Severe comorbidities, such as uncontrolled hypertension, heart failure, etc; 5. Pregnant or lactating women; 6. Previous history of malignant tumors; 7. Refusal or inability to sign the informed consent form for participating in the trial.