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NCT06317896

Value of Dynamic Monitoring of Early Recurrence of Hepatocellular Carcinoma After Radical Resection Based on CTCS

Sponsor: Zhujiang Hospital

View on ClinicalTrials.gov

Summary

On the basis of previous retrospective studies, the Task Force will further optimize the CTCs longitudinal surveillance model and initially validate the subclonal origin (CTC-DNA) of recurrent/metastatic foci derived from CTCs at the molecular level in hepatocellular carcinoma, prospective clinical trials will be conducted to further validate the predictive value of the CTCS longitudinal monitoring model in predicting postoperative recurrence of hepatocellular carcinoma, and to verify whether it is earlier than imaging to indicate recurrence, to explore the clinical feasibility of CTCs in guiding postoperative adjuvant therapy of liver cancer, and to provide new ideas for early intervention strategy of liver cancer after operation, to establish a set of standardized clinical scheme of auxiliary treatment for patients with liver cancer after operation for accurate and individualized"Early diagnosis and treatment".

Official title: Value of Dynamic Monitoring of Early Recurrence of Hepatocellular Carcinoma After Radical Resection Based on CTCS: a Prospective Cohort Study

Key Details

Gender

All

Age Range

18 Years - 75 Years

Study Type

OBSERVATIONAL

Enrollment

82

Start Date

2024-04-01

Completion Date

2026-12-31

Last Updated

2024-03-19

Healthy Volunteers

No

Interventions

DIAGNOSTIC_TEST

circulating tumor cells

blood sample and tissue specimen for circulating tumor cell and DNA will be done to patient with hepatocellular carcinoma

Locations (3)

The Sixth Affiliated Hospital of South China University of Technology

Foshan, Guangdong, China

Zhujiang Hospital of Southern Medical University

Guangzhou, Guangdong, China

Affiliated Cancer Hospital and Institute of Guangzhou Medical University

Guangzhou, Guangdong, China