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Comparison of Pacing Lead Design on Left Bundle Branch Pacing Outcomes: The LEAD_LBBP Randomized Clinical Trial
Sponsor: National University Hospital, Singapore
Summary
This trial seeks to evaluate the performance of the extendable helix, stylet-driven pacing lead (SDL) compared to the fixed helix, lumenless pacing lead (LLL) during left bundle branch pacing (LBBP), with respect to enduring left bundle branch capture on follow-up, incidence of acute lead failure, pacing characteristics including QRS duration, pacing thresholds, R-wave amplitudes and lead impedance, and finally, safety profile during LBBP implantation. These data will guide future lead selection during LBBP implantation in achieving improved procedural success and optimal lead performance.
Official title: Comparison of Pacing Lead Design on Left Bundle Branch Pacing Outcomes
Key Details
Gender
All
Age Range
21 Years - Any
Study Type
INTERVENTIONAL
Enrollment
210
Start Date
2023-01-01
Completion Date
2025-10-19
Last Updated
2025-06-06
Healthy Volunteers
Yes
Conditions
Interventions
Fixed helix, lumenless pacing lead.
Patients will be randomised to the fixed helix, lumenless pacing lead design during LBBP implantation.
Extendable helix, stylet-driven pacing lead.
Patients will be randomised to the extendable helix, stylet-driven pacing lead design during LBBP implantation.
Locations (1)
National University Heart Centre Singapore
Singapore, Singapore