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NOT YET RECRUITING
NCT06319131
NA

Nadroparin Versus TIPS in Cirrhotic Patients With Refractory Asymptomatic PVT

Sponsor: Shanghai Zhongshan Hospital

View on ClinicalTrials.gov

Summary

The purpose of this study is to evaluate the comparative effectiveness of nadroparin versus transjugular intrahepatic portosystemic shunt in cirrhotic patients with refractory asymptomatic portal vein thrombosis using a design of a multicenter, randomized controlled trial

Official title: Comparative Effectiveness of Nadroparin Versus Transjugular Intrahepatic Portosystemic Shunt in Cirrhotic Patients With Refractory Asymptomatic Portal Vein Thrombosis:a Multicenter, Randomized Controlled Trial

Key Details

Gender

All

Age Range

18 Years - 75 Years

Study Type

INTERVENTIONAL

Enrollment

84

Start Date

2024-05-01

Completion Date

2026-05-30

Last Updated

2024-03-21

Healthy Volunteers

No

Interventions

PROCEDURE

TIPS

Using the transjugular approach, TIPS was created under local anesthesia. The first branch of the left or right portal vein (PV) was punctured by RUPS-100 set guided by digital subtraction angiography. After successful access into PV, direct portography was performed and all visible varices and/or concurrent spontaneous portosystemic shunts (SPSS) were embolized with coils and n-butyl cyanoacrylate. A polytetrafluoroethylene-covered stent (Viatorr Endoprosthesis, GORE and Associates, Flagstaff, Arizona, USA) with a diameter of 8 mm was implanted and fully dilated.

DRUG

Nadroparin

Nadroparin calcium will be subcutaneously injected with the dose of 85IU/kg q12h