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Infusion of Prostacyclin vs Placebo for 72-hours in Mechanically Ventilated Patients With Acute Respiratory Failure
Sponsor: Pär Johansson
Summary
The purpose of this clinical trial is to investigate the efficacy and safety of continuous intravenous administration of low dose iloprost versus placebo for 72-hours, in 450 mechanically ventilated patients with infectious respiratory failure. The study hypothesis is that iloprost may be beneficial as an endothelial rescue treatment as it is anticipated to deactivate the endothelium and restore vascular integrity in patients suffering from respiratory failure caused by endothelial breakdown, ultimately improving survival.
Official title: Efficacy and Safety of 72-hour Infusion of Prostacyclin (1 ng/kg/Min) in Mechanically Ventilated Patients With Infectious Pulmonary Endotheliopathy - a Multicenter Randomized, Placebo-controlled, Blinded, Investigator-initiated Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
450
Start Date
2024-04-15
Completion Date
2027-09-30
Last Updated
2025-08-22
Healthy Volunteers
No
Interventions
Iloprost
Continuously infusion for 72 hours at 3 ml/hours. Treatment dose 1 ng/kg/min
Isotonic saline
Continuously infusion for 72 hours at 3 ml/hours
Locations (5)
Dept. of Anaesthesia and Intensive Care, Bispebjerg Hospital
Copenhagen, Denmark
Dept. of Intensive Care, Copenhagen University Hospital Herlev
Herlev, Denmark
Dept. of Anaesthesia and Intensive Care, Nordsjaelands Hospital
Hillerød, Denmark
Dept. of Intensive care, Hvidovre Hospital
Hvidovre, Denmark
Department of Anesthesia and Intensive Care Medicine, Zealand University Hospital
Køge, Denmark