Clinical Research Directory
Browse clinical research sites, groups, and studies.
Spontaneous Eye Blinking in Disorders of Consciousness
Sponsor: Fondazione Don Carlo Gnocchi Onlus
Summary
Differential diagnosis between Unresponsive Wakefulness Syndrome (UWS) and Minimally Conscious State (MCS) is complicated due to severe cognitive and/or sensorimotor deficits in these patients. In this study the investigators aimed at exploring the diagnostic and prognostic validity of spontaneous eye blinking parameters (rate, amplitude, duration, variability) in a sample of patients with Disorders of Consciousness (DoC). This is a multi-center prospective observational study conducted in patients with Severe Acquired Brain Injury (sABI) and DoC admitted to 8 European participating centers, with clinical data collection not deviating from routine practice. The study is non-commercial and will have a maximum total duration of 24 months.
Official title: Spontaneous Eye Blinking as a Diagnostic and Prognostic Marker in Patients With Disorders of Consciousness After Severe Acquired Brain Injury
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
70
Start Date
2025-03-31
Completion Date
2026-06
Last Updated
2025-09-29
Healthy Volunteers
Yes
Conditions
Locations (8)
Coma Science Group, GIGA-Consciousness, University of Liege
Liège, Belgium, Belgium
Therapiezentrum Burgau
Burgau, Germany, Germany
Dipartimento di Neurologia, LMU Hospital, LMU Munich
Munich, Germany, Germany
Polo Specialistico Riabilitativo Fondazione Don Carlo Gnocchi ONLUS
Sant'Angelo dei Lombardi, AV, Italy
Unità Gravi Cerebrolesioni - Dipartimento Neuroscienze - Azienda Ospedaliera - Universitaria Ferrara
Ferrara, Italy, Italy
IRCCS Fondazione Don Gnocchi ONLUS
Florence, Italy, Italy
IRCCS Santa Maria Nascente Fondazione Don Gnocchi ONLUS
Milan, Italy, Italy
Instituto de Rehabilitación Neurológica IRENEA
Valencia, Spain, Spain