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COMPLETED
NCT06323161
PHASE3

A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in People With Type 2 Diabetes Treated With Once-daily Basal Insulin With or Without Metformin

Sponsor: Novo Nordisk A/S

View on ClinicalTrials.gov

Summary

This study will look at how much CagriSema helps people with type 2 diabetes lower their blood sugar and body weight. CagriSema is a new investigational medicine. Doctors may not yet prescribe CagriSema. CagriSema will be compared to a "dummy" medicine (also called "placebo") that has no effect on the body. Participant will get either CagriSema or "dummy" medicine and which treatment they get is decided by chance. Participant will take the study medicine together with their current diabetes medicine (once-daily insulin with or without metformin). For each participant, the study will last for about one year.

Official title: Efficacy and Safety of Co-administered Cagrilintide and Semaglutide (CagriSema) s.c. in Doses 2.4 mg/2.4 mg and 1.0 mg/1.0 mg Once Weekly Versus Placebo in Participants With Type 2 Diabetes as Add on to Once-daily Basal Insulin With or Without Metformin

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

274

Start Date

2024-03-26

Completion Date

2025-10-23

Last Updated

2026-09-09

Healthy Volunteers

No

Conditions

Interventions

DRUG

Cagrilintide

Participants will receive once-weekly cagrilintide subcutaneously.

DRUG

Semaglutide

Participants will receive once-weekly semaglutide subcutaneously.

DRUG

Placebo

Participants will receive placebo matched to cagrilintide and semaglutide subcutaneously.

Locations (61)

Valley Research

Fresno, California, United States

Valley Clinical Trials, Inc.

Northridge, California, United States

Bioclinical Research Alliance

Miami, Florida, United States

Solaris Clinical Research

Meridian, Idaho, United States

Iowa Diab & Endo Res Center

West Des Moines, Iowa, United States

Alliance for Multispec Res

Newton, Kansas, United States

Endo and Metab Consultants

Rockville, Maryland, United States

Elite Research Center

Flint, Michigan, United States

Palm Research Center Inc.

Las Vegas, Nevada, United States

University of North Carolina

Chapel Hill, North Carolina, United States

Holston Medical Group

Kingsport, Tennessee, United States

Clinical Research Associates

Nashville, Tennessee, United States

Velocity Clinical Res-Dallas

Dallas, Texas, United States

Synergy Groups Medical

Houston, Texas, United States

PlanIt Research, PLLC

Houston, Texas, United States

Simcare Medical Research, LLC

Sugar Land, Texas, United States

Manassas Clinical Research Center

Manassas, Virginia, United States

TPMG Clinical Research

Newport News, Virginia, United States

Chinese People's Liberation Army General Hospital-Endocrinology

Beijing, Beijing Municipality, China

Huaihe Hospital of Henan University-Endocrinology

Kaifeng, Henan, China

Huaihe Hospital of Henan University

Kaifeng, Henan, China

The Second Affiliated Hospital of Nanjing Medical University-Endocrinology

Nanjing, Jiangsu, China

The Second Affiliated Hospital of Nanjing Medical University_Nanjing

Nanjing, Jiangsu, China

The Affiliated Hospital of Jiangsu University-Endocrinology

Zhenjiang, Jiangsu, China

Jinan Central Hospital

Ji'nan, Shandong, China

Jinan Central Hospital

Jinan, Shandong, China

Shanghai Pudong New Area People's Hospital-Endocrinology

Shanghai, Shanghai Municipality, China

Manda Memorial Hospital_Internal Medicine

Sapporo-shi, Hokkaido, Hokkaido, Japan, Japan

Tsuruma Kaneshiro Diabetes Clinic_Internal medicine

Yamato-shi, Kanagawa, Japan

Kumanomae Nishimura Naika Clinic_Internal Medicine

Arakawa-ku, Tokyo, Japan

Akaicho Clinic

Chiba-shi, Chiba, Japan

Futata Tetsuhiro Clinic Meinohama_Internal medicine

Fukuoka-shi, Fukuoka, Japan

Kunisaki Makoto Clinic

Fukuoka-shi, Fukuoka, Japan

Sasaki Internal Medicine

Hokkaido, Japan

Naka Kinen Clinic_Internal medicine

Ibaraki, Japan

H.E.C Science Clinic_Internal Medicine, Diabetes

Kanagawa, Japan

H.E.C Science Clinic

Kanagawa, Japan

Kyoto University Hospital_Department of Diabetes, Endocr

Kyoto-shi, Kyoto, Japan

Minami Akatsuka Clinic_internal medicine

Mito-shi, Ibaraki, Japan

Tokyo-Eki Center-building Clinic_Internal Medicine

Tokyo, Japan

Tokyo-Eki Center-building Clinic

Tokyo, Japan

Fukuwa Clinic_Internal Medicine

Tokyo, Japan

Kato Clinic of Internal Medicine_Internal Medicine

Tokyo, Japan

Healthcare centre Zvezdara

Belgrade, RS, Serbia

Healthcare centre Kragujevac

Kragujevac, RS, Serbia

University Clinical Centre Nis

Niš, RS, Serbia

Healthcare centre Nis

Niš, RS, Serbia

Policlinic for diabetes

Zaječar, Serbia

MOMED, s.r.o

Kráľovský Chlmec, Slovakia

DIA - KONTROL s.r.o.

Levice, Slovakia

SIN AZUCAR s.r.o.

Malacky, Slovakia

ENRIN, s.r.o.

Rimavská Sobota, Slovakia

LUDIA, s. r. o.

Spišská Nová Ves, Slovakia

Oraderumaz (Pty) Ltd

Bloemfontein, Free State, South Africa

Hemant Makan

Johannesburg, Gauteng, South Africa

Lenasia Clinical Trial Centre

Lenasia, Gauteng, South Africa

Prinshof Medical Campus

Pretoria, Gauteng, South Africa

Clinical Trial Systems (CTC)

Pretoria, Gauteng, South Africa

Dr Vawda's site

Durban, KwaZulu-Natal, South Africa

Ashmed Medi-Centre

Cape Town, Western Cape, South Africa

Dr Noeth's Practice

Pretoria, South Africa