Clinical Research Directory
Browse clinical research sites, groups, and studies.
IMProving DRug Dosing and Outcomes for Single VEntricle Patients With Fontan Associated Liver Disease
Sponsor: Children's Mercy Hospital Kansas City
Summary
This is a single center, open-label, prospective, investigation to quantify the effects liver congestion and fibrosis has on hepatic drug metabolism and transport in children, adolescents, and young adults with Fontan circulation.
Key Details
Gender
All
Age Range
8 Years - Any
Study Type
INTERVENTIONAL
Enrollment
15
Start Date
2024-03-01
Completion Date
2026-12-31
Last Updated
2026-01-02
Healthy Volunteers
No
Conditions
Interventions
Sildenafil 10mg oral tablet (participants <20kg), or 20mg oral tablet (participants ≥20kg)
A single oral dose of sildenafil will be administered to all study subjects.
Pravastatin 20 mg oral tablet (ages <13 years), or 40 mg oral tablet (≥14 years)
A single oral dose of pravastatin will be administered to all study subjects.
Locations (1)
Children's Mercy Hospital
Kansas City, Missouri, United States