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Ro60 Expression in Macrophages in Sjogren's Disease
Sponsor: Centre Hospitalier Universitaire de Nice
Summary
Context: The Ro60 protein associates with YRNAs (or RNYs) to form the RoRNP complex, which regulates RNA surveillance and maturation. It is hypothesized that its impairment by nuclear penetration of the anti-Ro60 autoantibodies, would deregulate the anti-inflammatory response in monocytes/macrophages (Mo/Mp) in patients with Sjögren's disease (SD).
Official title: Ro60 Expression in Macrophages in Patients with Primary Sjogren's Syndrome
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2024-02-09
Completion Date
2025-05-09
Last Updated
2025-03-11
Healthy Volunteers
Yes
Conditions
Interventions
Positive serology for anti-SSA
Blood sample which detect serology for anti-SSA.
Locations (1)
CHU Nice
Nice, Alpes-Mritimes, France