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Exercise MRI to Evaluate Cardiorespiratory Fitness in Children With Heart Disease
Sponsor: University of Alberta
Summary
There are many barriers to heart-healthy lifestyles in pediatric patients with acquired and congenital heart disease. Investigators want to further understand how participants heart and skeletal muscles work together during exercise and evaluate the impact on cardiac function. To do this, the investigators will use magnetic resonance imaging (MRI) to scan the heart and skeletal muscles during exercises to assess blood flow, oxygenation and function.
Official title: Utilizing Exercise Cardiovascular and Skeletal Magnetic Resonance Imaging to Evaluate Factors Associated With Cardiorespiratory Fitness in Children With Acquired and Congenital Heart Disease
Key Details
Gender
All
Age Range
10 Years - 18 Years
Study Type
OBSERVATIONAL
Enrollment
20
Start Date
2025-01-20
Completion Date
2027-12-31
Last Updated
2026-03-16
Healthy Volunteers
No
Interventions
Exercise cardiac MRI Assessment
Participants will undergo a standard cardiac MRI to assess resting ventricular structure and function then complete an exercise cardiac MRI assessment using an MRI-compatible stepping ergometer.
Cardiopulmonary Exercise Test
Cardiopulmonary exercise testing will be performed using a cycle ergometer. Consistent with standard guidelines, workload will progressively increase (10W ramp protocol) such that peak oxygen consumption (VO2peak) is achieved within 8-12 minutes. VO2peak, VO2 at anaerobic threshold, peak power output (PPO), ventilation/carbon dioxide production (VE/VCO2) slope, peak heart rate (HR), and HR recovery at 1- and 3-minutes will be recorded. VO2peak will be converted to age-, weight, and sex-specific norms and a %predicted value.
Locations (1)
University of Alberta
Edmonton, Alberta, Canada