Clinical Research Directory

Inclusion Criteria: 1. The participants are community-dwelling elderly people living in Yuyuan community, Shanghai, aged 60-85 years old, with no gender restriction. 2. Non-AD patients. 3. The participants can complete the cognitive tests, biological sample collection, speech tests, neuroimaging examinations, and cooperate with the implementation of the whole process of research. 4. The participants agree to participate in this study and sign the informed consent form. Exclusion Criteria: 1. Participants who are suffering from severe mental illness, tumor cachexia, severe liver and kidney dysfunction and other serious physical diseases and unable to cooperate with the examination. 2. Participants who have visual or auditory impairment that hampers the completion of related examination. 3. Situations when magnetic resonance imaging or other examinations are contraindicated.